Swiss Plant Stem Cell Complex – PhytoCellTec™ Malus Domestica Fruit Cell Culture and Lecitin
Age control complex in a double vector system. Derived from rare Swiss apple species to protect skin stem cells and ensure longevity of skin cells. Clinically demonstrated:
In vitro: test conducted on umbilical cord blood stem cells
- a. Maintenance of stem cell growth.
- b. Protection against UV radiation.
- c. Delay of senescence.
- d. DNA repair.
- e. Protection against oxidative stress.
- a. Turnover of the epidermis is more similar to that in young skin
- b. Activates the cell renewing process
- c. After 28 days, significant decrease in wrinkle depth for 100% of subjects. After 28 days 16% decrease in wrinkle depth.
- Skin Stem Cell extends life span of cells and activate the cell renewing process- cell Rejuvenation. Combats chronological aging.
- Biometic Peeling = Peptide 3 leads to increased desquamation of stratum corneum.
- Controlled delivery- The Vector system, using Liposomes, facilitates the penetration of the Plant stem cell into deeper skin layers.
- Reduces fine lines and uneven pigmentation.
- Improves smoothness, clarity and radiance.
- Plant stem cells are totipotent.
The Biomimetic Skin Growth factor Protector- Linefactor™
Unlike other know growth factors that address the TGF and EGF this introduces an innovation that targets the FGF-2 (Fibroblast Growth Factor), stimulating both cell multiplication as well as collagen and GAG’s synthesis. The FGF-2 is very fragile and diminishes with age. The LinefactorTM has been developed to have a PG-like biomimetic action toward the FGF-2 to protect and reactivate dermal synthesis.
Clinically demonstrated: study with volunteers ages 40-50, 50-60
- a. Makes skin 10 years younger.
- b. Effects on GAG synthesis appreciably higher than with Vitamin C and peptides.
- c. Corrects loss of elasticity
- d. Increased skin density, firming and texture after 42 days to a greater extent than Vitamin C.
- e. Reduces wrinkle depth.
A small peptide with a unique sequence to mimic the human body’s mechanism to produce collagen by activating
TGF-2. Clinically demonstrated:
- a. Stimulates collagen synthesis
- b. Actively removes any type of wrinkle
- c. Has skin firming and moisturizing properties.
An age control complex of Carnosine and Lemon balm extract in a double Vector system that prevents aging as anti- glycation activity and anti-inflammatory activity.
Clinically demonstrated after 28 days:
- a. Significant increase in skin firmness, elasticity, hydration and smoothness
- b. Anti-glycation activity counteracts stiffening of the collagen and strengthens the extracellular matrix.
- c. Has anti- inflammatory effects and fights UV induced skin aging.
- d. Inhibits the MMP’s from braking down collagen.
Summary of other key active ingredients and clinical studies
Palmitoyl Pentapeptide – 4, (Matrixyl™, 4.5%), containing Micro- Collagen™, (a synthetic
miniature fragment of collagen that is cited to initiate stimulation of collagen synthesis). Clinically
demonstrated to:
miniature fragment of collagen that is cited to initiate stimulation of collagen synthesis). Clinically
demonstrated to:
- A. Stimulate the fibroblasts to synthesize collagen I, and VI, fibrectin, and
glycosaminoglycans (GAG’s) both in vitro and ex-vivo studies. - B. Increase skin density and thickness
- C. Decrease wrinkle depth density and volume.
- D. Exceeds retinol results without the negatives ( pro-inflammatory reactions,
thinning of the skin-destructive effect on skin barrier, sensitivities). - E. Exceeds results of Vitamin C (skin density, volume and wrinkle reduction)
- F. In a study comparing it to TGFB1 (Transformation Growth Factor) and Vitamin C,
Matrixyl produced 217 percent rate of collagen synthesis TBFG1 produced 133 percent and Vitamin C a 142 percent
rate of growth.
Phytokine® – The Cutaneous Firmness Restoring Agent –
(biotechnologically modified Soy Protein) . It restructures the dermis, specifically reactivates neo synthesis of
elastin, GAG’s, collagen, the essential components in dermis that support the cutanous tissue. It offers a
reduction of the collagen III/collagen I ratio.
(biotechnologically modified Soy Protein) . It restructures the dermis, specifically reactivates neo synthesis of
elastin, GAG’s, collagen, the essential components in dermis that support the cutanous tissue. It offers a
reduction of the collagen III/collagen I ratio.
“Ex vivo” 3D Clinical studies demonstrated that Phytokine:
- A. Stimulated synthesis of the GAG’s (GlycosAminoGlycans) of aged skin by 66%.
- B. Promoted fibroblastic collagen formation by 65%
- C. Promoted Hyaluronic Acid formation by 74%. Helping to reconstruct the cutaneous
tissue , restoring hydration and improving elasticity and firming of the skin. - D. Causes neo-synthesis of dermic components involved in maintenance of cutaneous
hydration of the skin.
Ameliox – A Liposomal complex of Carnisone (di-peptide) and
Silymarin prevent the cross linking and stiffening of collagen that is caused by glycation and protects the skin
against oxidative stress. Dermatological test results showed:
Silymarin prevent the cross linking and stiffening of collagen that is caused by glycation and protects the skin
against oxidative stress. Dermatological test results showed:
- A. Immediate smoothing effect
- B. Reduction of frown lines
- C. Improvement in skin firmness
- D. Visible reduction of lines and wrinkles
- E. Slows development of new wrinkles
Malachite Extract – derived from the semi precious stone
- A. Fortifies the skin
- B. Protects skin cells against pollution and hostile environment
Sodium Hyaluronate
Paraben and Fragrance Free
Summary of Clinical Studies of new Key Ingredients for Cellasis™ Collagen Forming Crème:
Swiss Plant Stem Cell Complex – PhytoCellTec™ Malus Domestica Fruit Cell Culture and Lecitin
Age control complex in a double vector system. Derived from rare Swiss apple species to protect skin stem cells and ensure longevity of skin cells. Clinically demonstrated: In vitro: test conducted on umbilical cord blood stem cells
- a. Maintenance of stem cell growth.
- b. Protection against UV radiation.
- c. Delay of senescence.
- d. DNA repair.
- e. Protection against oxidative stress.
- a. Turnover of the epidermis is more similar to that in young skin
- b. Activates the cell renewing process
- c. After 28 days, significant decrease in wrinkle depth for 100% of subjects. After 28 days 16% decrease in wrinkle depth.
- Skin Stem Cell extends life span of cells and activate the cell renewing process- cell Rejuvenation. Combats chronological aging.
- Biometic Peeling = Peptide 3 leads to increased desquamation of stratum corneum.
- Controlled delivery- The Vector system, using Liposomes, facilitates the penetration of the Plant stem cell into deeper skin layers.
- Reduces fine lines and uneven pigmentation.
- Improves smoothness, clarity and radiance.
- Plant stem cells are totipotent.
The Biomimetic Skin Growth factor Protector- Linefactor™
Unlike other know growth factors that address the TGF and EGF this introduces an innovation that targets the FGF-2 (Fibroblast Growth Factor), stimulating both cell multiplication as well as collagen and GAG’s synthesis. The FGF-2 is very fragile and diminishes with age. The LinefactorTM has been developed to have a PG-like biomimetic action toward the FGF-2 to protect and reactivate dermal synthesis.
Clinically demonstrated: study with volunteers ages 40-50, 50-60
- a. Makes skin 10 years younger.
- b. Effects on GAG synthesis appreciably higher than with Vitamin C and peptides.
- c. Corrects loss of elasticity
- d. Increased skin density, firming and texture after 42 days to a greater extent than Vitamin C.
- e. Reduces wrinkle depth.
Clinically demonstrated:
In Vitro
- a. 48% synthesis of de novo collagen I.
- b. 62% synthesis of fibronectin.
- c. 45% synthesis of hyluronic acid.
- d. Gene activation involved in skin repair and wound healing.
23 panelists age 39 to 74 applied twice daily for 2 months 3% Matryxil™ 3000.
- a. Reduction of 45% in deep wrinkles
- b. Reduction of 15% in skin roughness
- c. Significant Improvement in elasticity and skin tone
- d. Significant increase in epidermal density and thickness.
- a. A significant increase in firmness of 19% in face and 40% in neck
- b. Elasticity increase of 17% face and 27% neck
- c. Decrease of 56% in deepest wrinkles
A small peptide with a unique sequence to mimic the human body’s mechanism to produce collagen by activating TGF-2.
Clinically demonstrated:
- a. Stimulates collagen synthesis
- b. Actively removes any type of wrinkle
- c. Has skin firming and moisturizing properties.
Benefits:
- Helps skin restore enhanced cell function.
- Facilitates keratinocyte and fibroblast proliferation while providing antioxidant protection.
- Fights dehydration by controlling ion flux.
- Visibly decreases skin sagging.
- Improves skin density, firmness, elasticity and moisture.
- a. Skin density increased 65% after 2 months use twice a day.
- b. Firmness increased 28%
- c. Elasticity increased 19%
- d. 30% decrease in “crepe paper” aspect of skin
- e. Decrease of sagginess of the neck observed by 67%
- a. 63% recognized firmer and less sagging of skin
- b. 69% saw their skin less “crepe paper” like.
- c. 59% reported improved skin tone and elasticity.
- d. 75% satisfaction with skin moisturization.
- a. 246% increase in keratinocyte proliferation.
- b. 135% increase in SAM enzymatic activity.
- c. Stimulation of keratinocyte: 323% increase in keratin synthesis, 943% increase in filaggrin synthesis, 814% increase in transglutaminase activity.
Clinically demonstrated In Vivo tests: 25 female volunteers used twice daily 2.5% emulsion for 56 days:
- There was significant decrease of the double chin volume by 1 to 2 ml for 64% of the volunteers.
- There was a significant decrease of the double chin fat for 88% of the volunteers.
