Summary of Clinical Studies of new Key Ingredients for Cellasis™ Collagen Forming Serum:

Swiss Plant Stem Cell Complex – PhytoCellTec™ Malus Domestica Fruit Cell Culture and Lecitin

Age control complex in a double vector system. Derived from rare Swiss apple species to protect skin stem cells and ensure longevity of skin cells. Clinically demonstrated:

In vitro: test conducted on umbilical cord blood stem cells
  • a. Maintenance of stem cell growth.
  • b. Protection against UV radiation.
  • c. Delay of senescence.
  • d. DNA repair.
  • e. Protection against oxidative stress.
In vivo: study with 20 volunteers aged 37 to 64 using 2% PhytoCellsTec for 28 days
  • a. Turnover of the epidermis is more similar to that in young skin
  • b. Activates the cell renewing process
  • c. After 28 days, significant decrease in wrinkle depth for 100% of subjects. After 28 days 16% decrease in wrinkle depth.
Benefits and claims:
  • Skin Stem Cell extends life span of cells and activate the cell renewing process- cell Rejuvenation. Combats chronological aging.
  • Biometic Peeling = Peptide 3 leads to increased desquamation of stratum corneum.
  • Controlled delivery- The Vector system, using Liposomes, facilitates the penetration of the Plant stem cell into deeper skin layers.
  • Reduces fine lines and uneven pigmentation.
  • Improves smoothness, clarity and radiance.
  • Plant stem cells are totipotent.
Hibiscus Abelmoschus Seed Extract-
The Biomimetic Skin Growth factor Protector- Linefactor™

Unlike other know growth factors that address the TGF and EGF this introduces an innovation that targets the FGF-2 (Fibroblast Growth Factor), stimulating both cell multiplication as well as collagen and GAG’s synthesis. The FGF-2 is very fragile and diminishes with age. The LinefactorTM has been developed to have a PG-like biomimetic action toward the FGF-2 to protect and reactivate dermal synthesis.

Clinically demonstrated: study with volunteers ages 40-50, 50-60
  • a. Makes skin 10 years younger.
  • b. Effects on GAG synthesis appreciably higher than with Vitamin C and peptides.
  • c. Corrects loss of elasticity
  • d. Increased skin density, firming and texture after 42 days to a greater extent than Vitamin C.
  • e. Reduces wrinkle depth.
Syn®-Coll – Palmitoyl Tripepetide-5

A small peptide with a unique sequence to mimic the human body’s mechanism to produce collagen by activating
TGF-2. Clinically demonstrated:
  • a. Stimulates collagen synthesis
  • b. Actively removes any type of wrinkle
  • c. Has skin firming and moisturizing properties.
Mellissa Officinalis Leaf Extract and Lecithin and Carnosine and Cyclodextrin – CiAge DV

An age control complex of Carnosine and Lemon balm extract in a double Vector system that prevents aging as anti- glycation activity and anti-inflammatory activity.

Clinically demonstrated after 28 days:
  • a. Significant increase in skin firmness, elasticity, hydration and smoothness
  • b. Anti-glycation activity counteracts stiffening of the collagen and strengthens the extracellular matrix.
  • c. Has anti- inflammatory effects and fights UV induced skin aging.
  • d. Inhibits the MMP’s from braking down collagen.

Summary of other key active ingredients and clinical studies

Palmitoyl Pentapeptide – 4, (Matrixyl™, 4.5%), containing Micro- Collagen™, (a synthetic
miniature fragment of collagen that is cited to initiate stimulation of collagen synthesis). Clinically
demonstrated to:
  • A. Stimulate the fibroblasts to synthesize collagen I, and VI, fibrectin, and
    glycosaminoglycans (GAG’s) both in vitro and ex-vivo studies.
  • B. Increase skin density and thickness
  • C. Decrease wrinkle depth density and volume.
  • D. Exceeds retinol results without the negatives ( pro-inflammatory reactions,
    thinning of the skin-destructive effect on skin barrier, sensitivities).
  • E. Exceeds results of Vitamin C (skin density, volume and wrinkle reduction)
  • F. In a study comparing it to TGFB1 (Transformation Growth Factor) and Vitamin C,
    Matrixyl produced 217 percent rate of collagen synthesis TBFG1 produced 133 percent and Vitamin C a 142 percent
    rate of growth.
Phytokine® – The Cutaneous Firmness Restoring Agent
(biotechnologically modified Soy Protein) . It restructures the dermis, specifically reactivates neo synthesis of
elastin, GAG’s, collagen, the essential components in dermis that support the cutanous tissue. It offers a
reduction of the collagen III/collagen I ratio.

“Ex vivo” 3D Clinical studies demonstrated that Phytokine:
  • A. Stimulated synthesis of the GAG’s (GlycosAminoGlycans) of aged skin by 66%.
  • B. Promoted fibroblastic collagen formation by 65%
  • C. Promoted Hyaluronic Acid formation by 74%. Helping to reconstruct the cutaneous
    tissue , restoring hydration and improving elasticity and firming of the skin.
  • D. Causes neo-synthesis of dermic components involved in maintenance of cutaneous
    hydration of the skin.
Ameliox – A Liposomal complex of Carnisone (di-peptide) and
Silymarin prevent the cross linking and stiffening of collagen that is caused by glycation and protects the skin
against oxidative stress. Dermatological test results showed:
  • A. Immediate smoothing effect
  • B. Reduction of frown lines
  • C. Improvement in skin firmness
  • D. Visible reduction of lines and wrinkles
  • E. Slows development of new wrinkles
Malachite Extract – derived from the semi precious stone
  • A. Fortifies the skin
  • B. Protects skin cells against pollution and hostile environment
Sodium Hyaluronate

Paraben and Fragrance Free


Summary of Clinical Studies of new Key Ingredients for Cellasis™ Collagen Forming Crème:


Swiss Plant Stem Cell Complex – PhytoCellTec™ Malus Domestica Fruit Cell Culture and Lecitin

Age control complex in a double vector system. Derived from rare Swiss apple species to protect skin stem cells and ensure longevity of skin cells. Clinically demonstrated: In vitro: test conducted on umbilical cord blood stem cells
  • a. Maintenance of stem cell growth.
  • b. Protection against UV radiation.
  • c. Delay of senescence.
  • d. DNA repair.
  • e. Protection against oxidative stress.
In vivo: study with 20 volunteers aged 37 to 64 using 2% PhytoCellsTec for 28 days
  • a. Turnover of the epidermis is more similar to that in young skin
  • b. Activates the cell renewing process
  • c. After 28 days, significant decrease in wrinkle depth for 100% of subjects. After 28 days 16% decrease in wrinkle depth.
Benefits and claims:
  • Skin Stem Cell extends life span of cells and activate the cell renewing process- cell Rejuvenation. Combats chronological aging.
  • Biometic Peeling = Peptide 3 leads to increased desquamation of stratum corneum.
  • Controlled delivery- The Vector system, using Liposomes, facilitates the penetration of the Plant stem cell into deeper skin layers.
  • Reduces fine lines and uneven pigmentation.
  • Improves smoothness, clarity and radiance.
  • Plant stem cells are totipotent.
Hibiscus Abelmoschus Seed Extract-
The Biomimetic Skin Growth factor Protector- Linefactor™

Unlike other know growth factors that address the TGF and EGF this introduces an innovation that targets the FGF-2 (Fibroblast Growth Factor), stimulating both cell multiplication as well as collagen and GAG’s synthesis. The FGF-2 is very fragile and diminishes with age. The LinefactorTM has been developed to have a PG-like biomimetic action toward the FGF-2 to protect and reactivate dermal synthesis.

Clinically demonstrated: study with volunteers ages 40-50, 50-60
  • a. Makes skin 10 years younger.
  • b. Effects on GAG synthesis appreciably higher than with Vitamin C and peptides.
  • c. Corrects loss of elasticity
  • d. Increased skin density, firming and texture after 42 days to a greater extent than Vitamin C.
  • e. Reduces wrinkle depth.
Matryxil™ 3000-  Contains the the Matrikines Pal-GHK and Pal-GQPR two peptides known as Palmitoyl Oligopepetide and Palmitoyl Tetrapeptide 7, messengers that act in synergy to repair skin. The combination of these two peptides results in a more powerful and dramatic anti aging effect.

Clinically demonstrated:

In Vitro
  • a. 48% synthesis of de novo collagen I.
  • b. 62% synthesis of fibronectin.
  • c. 45% synthesis of hyluronic acid.
  • d. Gene activation involved in skin repair and wound healing.
In Vivo

23 panelists age 39 to 74 applied twice daily for 2 months 3% Matryxil™ 3000.
  • a. Reduction of 45% in deep wrinkles
  • b. Reduction of 15% in skin roughness
  • c. Significant Improvement in elasticity and skin tone
  • d. Significant increase in epidermal density and thickness.
Another study on 17 subject using cream for one month:
  • a. A significant increase in firmness of 19% in face and 40% in neck
  • b. Elasticity increase of 17% face and 27% neck
  • c. Decrease of 56% in deepest wrinkles
Syn®-Coll – Palmitoyl Tripepetide-5 (2.5%)

A small peptide with a unique sequence to mimic the human body’s mechanism to produce collagen by activating TGF-2.

Clinically demonstrated:
  • a. Stimulates collagen synthesis
  • b. Actively removes any type of wrinkle
  • c. Has skin firming and moisturizing properties.
Essenskin™- The Fortifying and Restructuring agent. (2.5%)

Benefits:
  • Helps skin restore enhanced cell function.
  • Facilitates keratinocyte and fibroblast proliferation while providing antioxidant protection.
  • Fights dehydration by controlling ion flux.
  • Visibly decreases skin sagging.
  • Improves skin density, firmness, elasticity and moisture.
Clinically demonstrated in Vivo tests conducted on female volunteers mean age 60:
  • a. Skin density increased 65% after 2 months use twice a day.
  • b. Firmness increased 28%
  • c. Elasticity increased 19%
  • d. 30% decrease in “crepe paper” aspect of skin
  • e. Decrease of sagginess of the neck observed by 67%
Study of 100 consumers’ self assessment (mean age 60) using for 3 weeks:
  • a. 63% recognized firmer and less sagging of skin
  • b. 69% saw their skin less “crepe paper” like.
  • c. 59% reported improved skin tone and elasticity.
  • d. 75% satisfaction with skin moisturization.
Clinically demonstrated in In vitro:
  • a. 246% increase in keratinocyte proliferation.
  • b. 135% increase in SAM enzymatic activity.
  • c. Stimulation of keratinocyte: 323% increase in keratin synthesis, 943% increase in filaggrin synthesis, 814% increase in transglutaminase activity.
Ovaliss™-  Reduces and contours “double chin” , reshapes and improves facial contours

Clinically demonstrated In Vivo tests: 25 female volunteers used twice daily 2.5% emulsion for 56 days:
  • There was significant decrease of the double chin volume by 1 to 2 ml for 64% of the volunteers.
  • There was a significant decrease of the double chin fat for 88% of the volunteers.
Complete clinical studies of the above ingredients are available upon request.

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